RESILIENT & FOCUSED
Targeted support for a sharp mind and a resilient immune system — two formulas that work better together than either does alone.
MEMORY
MENTAL FOCUS
GUT BALANCE
IMMUNE SUPPORT
- Brain & Cognition for mental clarity, memory and focus — with omega 3 DHA, key B vitamins and brain-protective antioxidants
- Gut & Immunity for a healthy, balanced gut microbiome and stronger everyday immune defences
- Both designed for adults 50+, based on the science of ageing and UK nutrition research
There's a connection between these two products that isn't always obvious. The gut and brain are in constant communication — via what scientists call the gut-brain axis — which means what happens in one tends to affect the other. A balanced gut microbiome supports nutrient absorption. Better absorption means the brain gets more of what it needs. And a well-nourished brain is better placed to stay sharp.
After 50, both systems come under more pressure. Natural changes in gut bacteria can upset digestion and knock immunity. At the same time, the brain becomes more dependent on a consistent supply of nutrients like DHA, B vitamins and iron — precisely the ones that UK data shows many over-50s aren't getting enough of.
This bundle supports both, at once.
Brain & Cognition
The brain is a demanding organ. It accounts for just two percent of body weight but gets through around 20 percent of your daily energy and nutrients. That's a lot to ask of a diet that, for many people over 50, is already falling short in some key areas.
The formula starts with omega 3 DHA — the fatty acid that makes up a significant portion of the brain's grey matter and needs to be continuously replenished from food or supplements, since the body can't make it in meaningful amounts on its own. Each daily softgel provides 200mg of DHA from fish oil, alongside vitamin E to help protect it.
The capsule covers everything else the brain tends to need more of as we age. Pantothenic acid (vitamin B5), iron and iodine for cognitive function and mental performance. A full B vitamin complex — including B6, B12 and L-methyl folate — for nervous system support, mood and psychological function. Magnesium, often overlooked but important for both brain and nervous system health. And antioxidants including vitamin E, selenium, green tea and grape seed polyphenols to help protect brain cells from oxidative stress, which tends to quietly increase with age. BioPerine® is included throughout to support absorption — because even a well-formulated supplement is only as good as what the body can actually take in.
Gut & Immunity
Around 70 percent of your immune system lives in your gut. That single fact is the whole rationale for this formula — if you want to shore up your immune resilience, gut health is the logical place to start.
The centrepiece is SynBalance®, a clinically researched multi-strain blend of 14 live bacterial cultures including Lactobacillus and Bifidobacterium strains — the kinds most associated with a healthy, balanced microbiome. Two billion colony-forming units (CFUs) per capsule, every day.
The live cultures are supported by a carefully chosen set of immune-relevant nutrients that UK nutrition surveys consistently show are lacking in over-50 diets: vitamins A, C and D, iron, copper, selenium and B vitamins including B12 and folate. Calcium is included to support the digestive enzymes that break food down, and BioPerine® again to help the body absorb everything more effectively.
One capsule a day. That's the entire routine for this one.
Brain & Cognition — one capsule and one softgel daily, preferably together, with a cold drink at mealtimes. 28 capsules and 28 softgels per pack, 28-day supply.
Gut & Immunity — one capsule per day with a cold drink at mealtimes. 28 capsules per pack, 28-day supply. Suitable for vegans and vegetarians. Gluten-free.
Brain and Cognition
| Ingredient | Per capsule | % NRV* |
|---|---|---|
| Vitamin D3 | 20µg (800 IU) | 400% |
| Vitamin E | 26mg (ɑ-TE)# | 217% |
| Vitamin C | 80mg | 100% |
| Vitamin B1 (Thiamin) | 5mg | 455% |
| Vitamin B2 (Riboflavin) | 4.2mg | 300% |
| Vitamin B3 (Niacin) | 16mg (NE)# | 100% |
| Vitamin B6 | 10mg | 571% |
| Folic Acid | 200µg | 100% |
| Folate | 50µg | 25% |
| Vitamin B12 | 25µg | 1000% |
| Pantothenic Acid (vitamin B5) | 21mg | 350% |
| Magnesium | 60mg | 16% |
| Iron | 7mg | 50% |
| Zinc | 15mg | 150% |
| Copper | 1mg | 100% |
| Manganese | 2mg | 100% |
| Selenium | 110µg | 200% |
| Chromium | 40µg | 100% |
| Iodine | 150µg | 100 |
| Carnitine | 10mg | N/A |
| N-Acetyl L-Cysteine | 10mg | N/A |
| Grape Seed Extract | 25mg | N/A |
| Green Tea Extract 4:1 | 20mg | N/A |
| Co-Enzyme Q10 | 10mg | N/A |
| BioPerine® Black Pepper Extract |
3mg | N/A |
| Ingredient | Per softgel | % NRV* |
|---|---|---|
| Fish Oil of which Omega 3 including EPA including DHA |
500mg 300mg 30mg 200mg |
N/A |
| Vitamin E | 6mg (α-TE)# | 50% |
* Nutrient Reference Value #a-TE: alpha-Tocopherol Equivalent; NE: Niacin Equivalent
CAPSULE: Magnesium Oxide, Capsule Shell (Hydroxypropyl Methylcellulose), Vitamin C (Ascorbic Acid), Vitamin E (D-Alpha Tocopherol Acid Succinate), Pantothenic Acid (Calcium Pantothenate), Grape Seed (Vitis vinifera) Extract (Maltodextrin), Green Tea (Camellia sinensis) Extract, Zinc Oxide, Ferrous Fumarate, Vitamin B3 (Nicotinamide), N-Acetyl L-Carnitine Hydrochloride, Anticaking Agents (Tricalcium Phosphate, Magnesium Stearate), Vitamin B6 (Pyridoxine Hydrochloride), Vitamin D3 Prep (Cholecalciferol), Co-Enzyme Q10, N-Acetyl L-Cysteine, Thiamin (Thiamin Hydrochloride), Ferrous Citrate, Riboflavin, Manganese Citrate, Manganese Sulphate, BioPerine® Black Pepper (Piper nigrum) Extract, Copper Sulphate, Copper Citrate, Folic Acid, Sodium Selenite, Chromium Chloride, Potassium Iodide, 5-Methyltetrahydrofolic Acid, Vitamin B12 (Methylcobalamin).
SOFTGEL: Fish Oil, Capsule Shell (Bovine Gelatin, Glycerol), vitamin E (DL-a- Tocopheryl Acetate).
Gut and Immunity
| Ingredient | Per tablet | % NRV* |
|---|---|---|
| Vitamin A | 400µg (RE) | 50% |
| Vitamin D2 | 20µg (800IU) | 400% |
| Vitamin C | 40mg | 50% |
| Vitamin B6 | 1.4mg | 100% |
| Folic Acid | 200µg | 100% |
| Folate | 50µg | 25% |
| Vitamin B12 | 25µg | 1000% |
| Calcium | 120mg | 15% |
| Iron | 3mg | 21% |
| Copper | 1mg | 100% |
| Selenium | 110µg | 200% |
| Chromium | 30µg | 75% |
| BioPerine® Black Pepper Extract | 3mg | N/A |
| Synbalance® Multi Strain live Bacteria Blend | 2 Billion (2 x 109 CFU) | N/A |
* Nutrient Reference Value
Manufactured in a GMP (Good Manufacturing Practice) facility in the UK
Calcium Carbonate, SynBalance® Multi Strain Live Culture Blend (Bifidobacterium lactis, Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium breve, Lactobacillus casei, Bifidobacterium bifidum, Bifidobacterium infantis, Bifidobacterium longum, Lactobacillus bulgaricus, Lactobacillus reuteri, Lactobacillus salivarius, Lactobacillus paracasei, Streptococcus thermophilus), Capsule Shell (Hydroxypropyl Methylcellulose), Vitamin C(Ascorbic Acid), Anticaking Agent (Ascorbyl Palmitate), Vitamin D2 Prep, Ferrous Fumarate, Bulking Agent (Maltodextrin), Vitamin A Prep (Vitamin A Acetate), Bioperine® Black Pepper (Piper nigrum) Extract, Copper Sulphate, Vitamin B6 (Pyridoxine Hydrochloride), Folic Acid, Sodium Selenite, Chromium Chloride, 5-Methyltetrahydrofolic Acid, Vitamin B12 (Methylcobalamin).
Suitable for vegans and vegetarians.
Gluten Free.
Food supplements should not be used as a substitute for a varied and balanced diet or a healthy lifestyle. If you are pregnant, breastfeeding, taking any medication or are under medical supervision, please consult a doctor or pharmacist before taking supplements. If you suffer any adverse reaction whilst using a supplement, discontinue use and consult your doctor. Keep out of reach of children. Allergens are highlighted in bold within the ingredients list.
Who’s it for?
Anyone over 50 who wants to look after their mental sharpness and their immune health — rather than treating them as separate problems. It works well as a daily pairing for people who've noticed changes in their focus or memory, who feel like their immune system could do with some reinforcing, or who simply want to cover both bases without needing to research and build a stack themselves.
The Healthy Ageing Blend
Most supplements in the Prime Fifty range include our Healthy Ageing Blend: important vitamins and minerals often lacking in 50+ diets, according to UK diet and nutrition data.
The blend includes vitamin D to support bones, muscles and immunity, B vitamins for energy and a healthy heart, zinc for immune and cognitive support, antioxidants to help protect cells from oxidative stress, and chromium for healthy blood sugar balance. Where possible, these important nutrients are always added, no matter which health area you’re targeting.
Together with BioPerine®, a patented black pepper extract shown to support absorption, these nutrients build a strong foundation for your health as you age.
Targeted support for brain health and mental performance
The brain is very demanding when it comes to nutrition, making up just two percent of the body but using 20 percent of our daily energy and nutrients. As we age, natural changes in both nutrition and brain structure can make it harder to satisfy those needs consistently.
Prime Fifty’s Brain & Cognition is designed specifically for people over 50 based on how our needs change with age. Taken once a day, Brain & Cognition helps support a healthy brain and mental performance, so you can feel focused and confident.
Beauty from within — nourished at the source
Collagen is the structural protein that keeps skin firm, hair strong and nails healthy. After 50, your body makes less of it — and it shows. Collagen delivers 5,000mg of high-strength marine collagen peptides daily, broken down for easy absorption, so it can reach the tissues that actually need it.
"About 70 percent of our immune system is located in the gut, so maintaining a healthy microbiome becomes even more important as we get older. I designed this formulation to combine carefully selected friendly bacteria with key immune-supporting nutrients that many over-50s are lacking, to support both digestive health and everyday resilience."
Vitamin A, vitamin D, vitamin C, folic acid, vitamin B12, iron, copper and selenium all help support the normal functioning of your immune system.
The balance of the gut microbiome is very sensitive to what we eat, and an unbalanced gut flora is linked to numerous health problems. We’ve added SynBalance®, a live culture, multi-strain blend of bacteria to help re-balance your gut microbiome.
This special blend includes 14 clinically tested strains, including Lactobacillus and Bifidobacterium, to encourage a healthy, regular digestion and a diverse microbiome, with two billion colony-forming units (CFUs) in every capsule. Plus we’ve added calcium to help digestive enzymes break down and absorb nutrients from your food.
Did you know that your brain is about 60 percent fat? The fatty acid DHA (docosahexaenoic acid) is a key building block for the brain, especially grey matter, essential for mental functions like memory, emotion and movement.
The brain’s DHA needs to be continually replaced in small amounts every day, as it’s constantly being metabolised and degraded by oxidative stress. To keep up the supply, we need to obtain DHA from our diets, typically from oily fish like sardines, mackerel and salmon.
Each daily Brain & Cognition softgel provides 200mg of DHA from fish oil to help maintain a healthy brain and sharp mental focus.
Customer testimonials
Lisa H
Highly recommend these
I kept having sickness with sulphur burps have suffered for years thought I would give these a go and they have stopped the sickness and sulphur burps highly recommend these
Tom B
Clears the brain of all the fog
Works well, clears the brain of all the fog , and helps with reading and watching TV. I feel much better for taking them especially with my concentration.
Verified Customer
I have certainly noticed a difference in my energy levels and a positive change in my memory
I have recently purchased Prime Fifty Brain & Cognition and in the short term of taking the supplements I have certainly noticed a difference in my energy levels and a positive change in my memory which has given me more confidence in work and helped towards such a demanding role. A great selection of ingredients, will definitely continue taking them and re-order when needed.
FAQ
For honest help and advice, our award-winning team is here Monday to Friday from 9am to 5pm.
Freephone 0800 107 5995
From outside the UK
+44 (0) 1223 750 874
Do you ship overseas?
Yes, we ship all over the world. Shipping costs will apply.
How long until I feel a benefit?
This can vary from person to person, and also depends on the product and the benefit you're looking for. Supplements aren't pharmaceutical drugs, and they won't have an immediate effect.
Some supplements work in the background, delivering long-term health benefits without noticeable short-term differences.
But for most products, the active ingredient in your supplement needs to build up to sufficient levels in the body to begin to have an effect. In general, you should notice a benefit after 4-8 weeks of supplementation.
If you have a question about a specific product, please contact our Customer Care team for more detailed advice. hello@primefifty.com
I’m taking prescribed medication. Can I still take supplements?
If you’re taking any medication or are under medical supervision, please make sure that you consult a doctor or pharmacist before taking any supplements.
How do your subscriptions work and how do I pay for them?
Our subscriptions are designed to make life easier and ensure you never run out of your supplements.
Once subscribed, your order is automatically processed and delivered based on your chosen schedule – every 28 days.
Payments are processed automatically at the start of each subscription cycle, so you don’t need to worry about reordering manually.
You’ll receive a 3-day reminder before each shipment, and our subscriptions are fully flexible – you can amend, pause, or cancel at any time to suit your needs.
From the journal
Why Prime Fifty?
We believe ageing isn’t about limitation. It’s about supporting your body to stay capable, active, capable and independent. Prime Fifty is here to help you live the life you want to live.
What your body needs after 50 that it didn't need before
Living longer sounds good, but living well is what matters. Discover how your nutritional needs change after 50 and what the science says about maintaining strength, clarity and resilience.
Discover our Healthy Ageing Blend
As well as targeted support for your health goals, most Prime Fifty supplements also include our Healthy Ageing Blend – extra vitamins, minerals and nutrients that help to build a strong foundation for your health as you age.
- MDMiss D. S.Verified BuyerReviewingGUT & IMMUNITYI recommend this productRated 5 out of 5 stars3 months agoGut & Immunity
Great product
- SSandyVerified BuyerReviewingGUT & IMMUNITYI do not recommend this productRated 1 out of 5 stars4 months agoGut & Immunity
I ordered a 3 month supply in August but another order arrived in November and money taken out of my bank account. After phone calls & emails this unwanted order was sent back and eventually the money was replaced in my bank. Clearly the ordering system was not clear & I found it quite stressful.
- MDMiss D. S.Verified BuyerReviewingGUT & IMMUNITYI recommend this productRated 5 out of 5 stars5 months agoGut & Immunity
They are good they keep my gut nice and healthy
- MAMrs A. P.Verified BuyerReviewingBRAIN & COGNITIONI recommend this productRated 5 out of 5 stars6 months agoBrain & Cognition
Have been using this product for quite a long time, and I never feel let down . Can definite. recommend. The service is absolutely first class.
- PDPhyllis D.Verified BuyerReviewingBRAIN & COGNITIONI recommend this productRated 5 out of 5 stars6 months agoBrain & Cognition
Highly effective